Enzyme Inhibition in Microorganisms

Enzyme Inhibition Competitive Inhibition. Non-Competitive Inhibition. H inhibits the activity of enzyme. competitive Inhibition The Substrates complete for the active site of enzyme so the required pdt will not be produced Succinate Succinate Fumarate dehydrogenanc Malonic acid resembles succinate, so malonic acid come and bind to the active site of the enzyme succinate dehydrogenan So fumarate will be formed. of microbial disease. Application - It is used in many treatment to For eg. bacteria requires folic and to grow. P - amino benwaate is used as substrate for folic acid production p-aminobenzoate folate synthase folic acid (substrate) (pdt) (suyfactory) Suffanomiste resembles with the p-aminobenzoate so competitive suganilamide Inhibition takes place no folic acid is formed and bateric dire. growth is inhibited. Human are not harmed because they don ot synthesize folic acid but rather obtain it in their did

Non Inhibition -They bind to Some location other than the Competitive active site. Hg binds and change the conformation / shape of en enzyme So the Substrate cannot bind to the active site due to the change So no polt/ less pdt will be formed.