Cellular Apoptosis: Implications in Immunity and Development

Apoplosis sandom reagangement of Bcells same cells selectively removal of sey dimlented morelly destructive immune cals (or trugeted to destruction Reas Ammundogs by programmed cell death tre -ve Programmed Cal death:- (PCD) chickens human bonding web removal ranoral of embryoric fails, aeroral of eselas neve connections in train(50%) Removal of aged cells. Naronal survival depends on recognition of target tissue (nevon) NGF Recognition of Teopic fadors N ff cells receive HIDDEAF this signals (survivalfactors) (Beain Delived) they servive Programmed cell death Absensce of survival signal secreation of death signal NKCP Macrophages 3types of cell death Necrosis Apolopsis Neorotopsis neiosis Apoptor (Pcb) Patrogon infected cell. disintegrate (cell volume nudeas Programmed paces cellshorst cyloplasmic contents vino Apoptatic pathway released as bluts not finally rupture the release bwhs recognised engolfed cell.and cause injlamattory respence, to contents hymacratages prevent vires proliferation Inflamattory seised hyonother

Apoplosis 1 Extrinsic palbway Intrinsic palturay some proteins are proapoloptic (pranote apoptersis Bad, Bid, Bim, Puma, Noxa Bak Bax antiapoplotic BC 12 ,BClxL Cytc Intermet space. outa memb BAK oligomenization prevented by BCL2 BAX Bad, Bid, Bimetccan remove BCL2 BAK& Bax oligomere Apaf deoxy a ATPcontainin proteintocytad. /pay +cytc Apal- d ADP Apoplosome complex activate easpase a (protecuse active site has cystein taget site by dimerization Aspartate Inliatorcaspase activate execution by caspases proleolytic cleavage Initiate Apoptav Casp 3,6,7 cleaved inactivate kinase required forcell survival.

1 Inactivatekinare Casp 3,6,7 FAK, PKB, PKC Raf. 2 Cleavage of 3 Activate Degrade Activate Hoppose Lamin CAD cylosteletal slighpase proteins Carpase Xkr-8 Activated DNASE Phosphalidyl Cleave DNA S from inner cooflet to oofer leglet eatme signal of Blohs. Impresaxe of trophicalas PK B activated P BAD cannot remove BCL2 P Inalsance PKB inactive BAD dephosphorylated removeBCL2

DNAdamage induce apoptoris ATM/ATR checkpoint P53 Puma f Noxa (TF) Remove BCI2 extracellola side fibring cells attached to ECMby integrin fibronectin etc inner side cytosteleton Cy to Skeleton disassambly Bim remove BCl2 In present ceoftrophic factors In abserce of Troph ic factor PKB activated PKBinactive Foxo 3A P foxo 3A : cannot enter enter nucloces nucleus Tfob Bad PUMA Crefer previous page)