Desestination

Desensitization (1) ski N. (ORd m Sin 3A active receptor enternucleus + coreceptors secrute activate HDAC (R2R3) bindto SmoN smadcomplex 1 PAI transcuption (2) Smad 7 - Inhibitorsmad ( (Ismad) - binds ligand occupied receptor frurther phosphorylation 3) Innucleus Phosphatase dephosphorylate smad Travel back to cytool Goootiffactors cylolinio execute same response Receptor nota tinase Bind directly toaceceptor associated witha kinase JAK JAKphosphorylates the receptor - RTK now it activates a kinase normally excisfin 1 PLCY monometic state STAT MAPK 4 P13 kinase PKB varual ligend ddimerizef 1338DAG pathway response autonhandrandal T.N

EGF Epidamal Growth factor PDGF Platelete Pained Goodth factor Neuronal Growth factor Ligreds allow dimerization NGF activation of receptor PGF Eurroblast Gowth factor except insules IGF Insolin Growth factor phosphorylate @ Tyr Insure So called RTK STAT Receptor Tyrosine kinase MAPK Activate various response PI3K PLCr Cytokines Interleokin Granolocyte Colony stimulating factor factor GCSF MCSF Macrophage colony stimulating GMCSF Grandocyte, monocyte colony stimulating factor. EPO Erythmpotten TPO Thrombopelin Proladin Recepter in mammary gland. Growth hormone Receptors contain not tiouse an Associated JAK- Just mother times a when Receptor ligard occupy receptor, JAK: activated Phospborylate the receptor nowthe receptor in atinase execute activation of various pathways PLCr STAT P13K MAPK