Cellular Aging

Cellular aging Factors causing Free radicle injury Protein misfolding Defective nutrient sensing : Autophagy Mutation Cellular senesence Permanant state beyond which cells can't replicate caused due to : Telomere shortening Somatic cells divide 60-80times Hay Flick limit Hay flick limit : No of times a cells can divide before it goes into senescence. 8 Lost

FACTORS / WAYS To DELAY AGEING 05:50 Glucose + IGF-1 Replication - Glucose activates IGF-1 - IGF -1 stimulates replication - Replication causes telomere shortening - Telomere shortening causes ageing a) Restricting calorie intake b) Activation of SIRTUINS : - NAD Dependent protein transacetylase - cell metabolism Glucose requirement - Cell Repair - Activates telomerase that maintains telomere length - Every cell has SIRTUINS - Activated by Red wine