Autophagy

Autophagy AUTOPHAGY 00:10 Process by which cell eats up it's own component. Physiological :- Ageing, Exercise Pathological :- . Cancer Tumor cell when severly deprived of nutrients. Neurodegenerative disease Alzeihmer & Huntingtons Infections :- MTB, Shigella, HSV-1 inflammatory Bowel disease. MECHANISM OF AUTOPHAGY 03:25 Nutrient Deprivation :- Cellular stress Cells destroyed Release of cytoplasmic orgenelles Organells bound by :- initiation complex Nucleation complex Initiator complex Plasma Nucleation complex Membrane INITIATION

you Lysosome Elongation Maturation Fusion of Lysosomes Degradation Elongation of plasma membrane occurs by Light Chain 2