Nervous system

24/9/M Nervous System Human train 100million cell 100 trillion syraps Brain central nervoos system Pecipheral Navous system Spiral Brain Cereforum Cerebellum coord Stern regulate language, motor Conduct learning, function breathing memoryetc Sensoryt of Chiqhe order motor blood functions info from pressure bodyfotrain

Navon develop intially from neuroblast cell (spherical) migrate long distance (elongation -arronformation) connect it to the targetcell Branching from cell body - -dendites - receive information from other neurons Long extended growth i'm in human train - ascons. } diameter mm in savids ofaxon covered in by decrease resistance swain cells & increase impolse velocity Myelin Sheath formation Increase impulse velocity Prevents short circute.

Cell body myelin sheath axonhillock on Dendsite ason dn action potentia - fomv +50mv hyperpolarias depolarization (50mv) (vision is aperaul repolarization (-70mv) hyperpdalization (-220mv). eboline Acetyl transferase (CAT) acetylchritine + acetyl COA acetyl eholine CoA. NH3+ NH3 CH - coo CH2 CH2 CH2 decarturation CH 2 CH2 coo coo Glutamate GABA raming Bolyst nourotronsmission acid inhibitor

ACTIVITY 'h TTA- NH3+ CH - coo I NH3+ CH2 NH3 decarboxylate CH CH2 1. attachone more CH3 CH 1-0H - OH OH O o Tyrosine OH OH OH OH norepinephris Dopamine neurotronsmission inhibitor DIPF, Orgorophorphonous pesticides all nevertonsmitters DIPF reuptake intact form except acetylchotine acetylcboline eastauace acetylcholine acetate + choline lowlevel Dopamine - -Parkinson's. Seratonine- - Depression monoamine oxidase cleave Dopaminef Saalosin N (CH3)3 I CH2 1 CH - -OH O OH OH Epinephrine

coo 2 YUCCA genes for CH2 -CH - Ntl3 Auxin synihesis tryptophan decarborylase & add 10H aninotrongfelase into Indole pyrovate OH CH2-CH2 -Ntb+ flavin monoorgenaue Indole acetic acid Seratonin (5hydroxy trystamine) Histidine Narotransmitton S. decarboxylass Histamine Excitery Inhibitory epotential Graded Action 1 denduite connect to local, several nerve, decrease do not deciea some region secreate excitary with with distance perotronsmitter distance E summation bind foreceptor effect No (breshold Threshold open Nat chanel value value E50 - 20mv) Mm Potential generated all/none response (below 20mv EPS P (Excitory Rest IPSP (Inhibitory Post Synaptic Potential no signal grapticidentill) inhibilary neuro (out) transduction) Excitery nevertoms (ib) millors open Nat chane, transmiltor binding of kt /cr mm more +ve; response action channel, create -ve potential potential generate at ason in cell ,no response genes billock The predomination of any of the 2 generat action potenti al

channel. Sodium channel Tetrameric protein Pais monomel the each protein 6 times through membrone (6 transmembrone 4 domains (each domain spons domains) 6times) domain inthespon 4th is S4 voltage sensingdomain voltage sensing each poly pepticle hasinactivation segment only 1 inactivation segment b/w 34 4th domain now bothoperate in action potential Cytosslic side - velychange lining. +ve charge on channel attractet -ve on membrone this close the channel In axon billock +ve enter cytosolic side repell with +ve chaige lead to opening of Nat channel require - 50 to - 20 -ve Open channel lining always positive,Cytos +ve close ionflow blocked by inactivation segment for immediate recovery k + channel open @ 50mv flowef +ve to extra repolarization our immediately

Exceller Nat Depolarized membrane & t + + + + + + + Cylond Inactive Na+ Closed Nat openNat Channel channel Channel Repolarization of membrane