Gene response system

25/9/14 Grand 1. position SP1 - GC Box binding protein Distal Elements Eschanars Silexcess Insulators activator represers Boundary + b/w agones co-activator corepreisors loop. loop Hormones as gene regulators Hormones Protein Steroid (cholestrol derived cannot enter into cell can enter cell Bind to receptors nucleus signal tranduction T3 T4, relinoic acid, cholestrol delived formones 2° messengerson eg:CHMP Biddle Cholestrol (C27) vitD3 all hormone C inty same Pregnanatone (C21) Progastagene (C21) Glucocortewoid Mineralocorter Andiogen Estrogen 1 (21) (C21) (C19) (C18)

,T4 hydroxylation (eg Benzopyeine /Ajlatoxin Rejer mutati CytP450 O2 +NAPH, monooxygenas Htcoridative branch of Ht). HMP produce NADPH, + H2O OH T.OXIN/Addocts] fasting state glocose PEPCK comissitted enzyme gluconiagenoxis required Target enzyme glocagone elevates. c [Protein] Adenyl cyclase IGPCR S GIGGTO CAMP H ATP PM. = PKA Liver Cell P CREBP Transcriptional Nucleus adivator (RE) responce elements CRE binds. (CAMPRE) CRE PEPCK (cisa HA recognised by [endrancel] bistons recruit co-activation CBP acett BPE CREBP allaformingloop. Tranfo CRE PEPCKI [CREBP Binding Protein

extranotes (spipfoontinue to next page) Responce elements BPE eg:- HRE (heat Shock Responce Element) HREBP GRE (Gluxocerticoid Respence Element) GREBP SRE (Steld Responce Element) SREBP endestrol bioxydheris unable toesper i accept H (delocalization - C - Cx I H 1 double & single bond oscillate O I - C N - Cx bond It length b/w singleddooble acctylation remove +ve change of histone (Refernote 1) [delocalizati as] reductors cholestrol symbosis, HMGCOA commi Hed enzyme, active endertrol sitefaces level lasthan 5% intermemb SREB cylood (enzyre inERmemb) (Protectylic deavageadivation] HONGICOA SREB nucleus HAT STREE synthesis endostrol.

bistone acetylated Pulled by Chromatin Remodelling Complex @ the Gene [SWI/SNF] (CRC) eg. sucrocose loosecharge switch irreggementing TATA box expened TBPbinds. Transcription