Steroid hormone action in genes

Stroid Hormone Receptorin Receptor in Cylorot restrictin HHSP70 nucleus cyloplasmby HSP Glucocorticoid inhibit Vit P3, RA, export Mineralocortccord intonucles. Thyroxine (T4) Estrogen Progestrone homodigmerize RECEBARE HSP70 Center in & (HSp90 notes) inverted repeats leaves Hsp70fHip90 removed after ligond handines binding binds stimulate transcription Receptors in nucleus beterodimes RE is direct repeats commonfactor ) RXR YDR specific factor [vitP3 Receptor) heleco Dince RXR TRE RXR RARE With ligand Withoot ligend Activators Repressers securite HAT Recruite HDAC Stimdate Inhibit transcription transcription

proble several Damin 13 Pa molif specific sequence that interact with DNA. Molif Eduayotic motifs Different motif on different Tf I HomeoDomain' 4 2 3 Basic Protein Zinclinger Leucine Helix Motif Molif zipper hoop Helix Motif (Hox) bindsmagon molif eg:0MIC groove of every god yth. Myo D (muscle developmer recidue us Tf) C2H2lype (FIIIA) C4 type Leucine, in that zipped SREB (stoid Read. Element BP) finger jinger stabilized position Tfof HMG COA stabilized by Haysteine. CREB red octone by 43inc GCN4inyeast Steradhormone (General control X12 receptors Cys His of Nitragenmedalzlim) X 47 Zn 132. Cys API (heterodime)). Cys His Cys Zn fos/JUN - -complex) in X3 t X3 cys Cys. EBILLY Interact with major grove X3-Cys- X 2-4 - Cys - X12- His - X2-4 - His - X3. Packaryete HelixTurn Helix Chac represor)