Modification of histones

Species lacking r health deficient Progeny Natural selection Eliminate the Progeny. Modification of Hiitone Epigenetic Phenomenon H4 KiG Ac histone acclylation Transcriptional activation 30nth llnin (Sdenoid) (Beads on dring) H3Bh A H3 527AC Transcriptional H3 (Me) - methylated only H3 SIO (p) aclivation. H2B K120(ub) Hzka (Me)3 H3 K27 (Me) Transcription H2 A K119 (ub) HM H3K smethyl Transferase HPI protein chronoshadow downain Holiz/(Me)3 Aggregate added. baschremodamain together Docking Sile for new HMT Sensequent methylation HPS

itement 'e3 10 curity 0000000008 welks. Barrier insulator Gene 2 Gene 1 Prevents active Inactive S preding Me3 Boundary afactivation to next gene HP1 element Anterior Posterior Segment Regulation in Dresophilla Different Segment Identity in diosophilla controlled boy Blycomb Thri thorax complex Horactivate Hox repressor PRC1 Transcriptional repressor. activator. complex (PRC) PRC2. Posteur or Transcriptional anteior repressor Trithorax complex wt ScM (PCG) motant P P A P A hoxin postcoir most Postelior segment Proper development throaghout, Anterior structure fail to develop. Dominate is anterlor. HDAC condensation. PRC2 2activity H3 1,27 MT anomoshadiow intraction PRCI (erromodomain complex) bind to K27 Me3 amornoshadow radivity Facilital e intraction aggregation H3li41 demethylase H2A K119(ub) Hox (AGB)