mTOR complex

- the . TOR Paltway Targel of Raparoycin Register by atrious multicelletar yeast Notrient, Growth factors, nutrients O2,ATP only Notrient L , GFL ,O2 , , AMPT AMP kinase Activating P 1: P It's a GAP TSG12 rotation leads to Tuberous Sclearosis GGES Rbcb-GTP Robb GDP MOTOR (melagoan) Nutriest GFT, O2 1, ATP RTK Inhibitory P TSCI/2, P 2 Rheb GDP Rheb GTP mTCR

ODTOR " pass for cell prodiciation Cling Cyclin D. (G1/5) r Translation TOTOR CITYLE globalterolation inhibitor regulator of 44 S6 (6th protein in small cinomial subonit) P kinase P CIFAA PDCD P CTF4B inhibit situous andremove PDCD4 actively engage intronslation CIF4A TTOR IviaS6 kinase P TIFIA securite RNA polI TF MTOR transcription of riboonal P gene MAF 1(Promote transcription) TOPMRNA (Track of oligo Pycamidamine) my RNAPOLIII isase free Translated (enchanced bymTOR) inhibiter office riboxmal protain Pol more tRNA III Efficient transl ation

Inhibit aulghagg MTOR Litcz Cjin sapamycin semilive.,activatecello division Regulate cell. shape change MTOR C2 Peomote actin polyinelization Rapamyain inscusitive Inhibit cell apoptoris. Translational Regulation RBClack nucleus most regulations translational level 98% globinprotein globin MRNA (120days) In absence of Balme globin translation inhibited eIr2B eIf2kinase GIEF geflevel Translation P P depletes XLB CIF2 Vapi dead COP end product