Oxygen depletion in cancer cells

p {margin: 0; padding: 0;} HIF not Nobel Peize - 2019 stabilized due to No O2 in centre of tumor growths hydroxylation of Brine byeroline hydroxylass Degradation Hypoxia inducing factor (HIF) not stabilized by objquitination 5 Pyrovate Pehydagame act as TF for several kinase gone 1 VEGF 3 Pyarate Glycolytic AcctylCaA Vaxulai Endothelial 2 DGWT Proteins Growth factor. genes enzymen genes more glot (Pehydogonari) P Promote 4 LDH moreglocose Proliferation tromblood glycolysic Block TCA. of blood lactate vasels gehydrogenase 6 (Angiogonosis) Pyrvate Lactate. Ery thropeitin 8 Tyrosine hydeoxylase anaerobic-plycolysis anythrocyte product promote breathing proliferation rate. 7 Nitric oxide Syntbase NO2 & Heme Oxygenax vasodialation by relaxation Anoolbmoscle cells.