Intrinsic and extrinsic pathway

Intrinsic Pattroay trophic factor receptor Trophicfactor presponces P P UD Procaspas Casp 3 t 2 Pl-3kinase 14.3.3 t P P BIM caspa Coopy 3 miao dimerize PKB Foxo - -3a tobole/ cytatella 14 Procaspase Casp9 9 TFOGBAD,BID,BM BAD inactivein P form] Bir P P 5 1433 Apaf 1 ATP ADP ATP BAD Cytc BCL /BCLXL mt memb. cyt C BAK/ BAX Nucles xpoox DNAdamage P53 P RUMA NOXA

Rp = Ns BL 1 (Reproductive Potential of Pasasite) no:ef Inxlongevity (Length of association for host) sale usesfihl Better parasite enter host symbictic mutualistic relationship cytc was weapon to releas kill bost nowthe same weapon used for PCD. BACTERIOPHAGE Plasmid enter bactelia Toxin production gones reside in Plasmids latersed for Extrinsic Pathway (FACDLigard on NKC) TNF- L scueated from malophage during infection activation. after Tumour Bind to TNfx receptor neactic factor receptor trimelize Incylorolic side recruite TRADD TNd Receptor Associated Death Domin Protein Remove BCl2 Require FRAD FAS LIGAND ASSOCIATED R DEATH Domain Protein Bid tBid. Dimeuze excetolional Activator Intialor casp Casp 8 CADD 367

1 Extrinsic Signalling cell PM. Responding cell. TRAFF FADD. Caspase 8 Bid tBid Procasp 3,6,7 Casp 3,6,7 Remove BCE2 & Bclx Necroptosis some virus inactivate Casp 8 Macrophage Soevade the extrinsic pallway TNFL r Trimelize cannotically activate cell cellborst. receptor Ca2+ elecrate incytool iceuvite only TRADD Phosphorylale &oligomenize MLKchannd RIP-J kinase MAN RIP-3