Cell Signalling

Cell signalling TGF B signalling Transforming Growth fador B (TGFB segretting) - proliferation Inhibit cell 3receptors R1 Rr R3 In some celltype R3 binds ligard and transfer to R2 or in some R2 binds to ligond and transfer to R3 ligardtR2+R3 actastinase P Smad 2/3 Regulatory smad + (co smad) Smad 4 enternudes Tf promote transcription of corresponding genes Targetgenes 1 PAI -Plasminages Cell proliferation Activating Inhibitor clot Dissolve Plasmin asminsaen Plastringgenactivation PAI (cannot looses ECM- Cellaycle

Liver lack E 3A & E3B (sociable) 2types of fibronectin by (souble) Exposere of Practivates integrin) (based ontype of fitrroblast bind to integeint Note cell recreating in Plasma m embrone it) Solid EIIIB applatelets exposing Aternatively Causeclot P 1-Sein splicedproduct EIIA zadditional excons. 2)Collagen ECM stability cell proliferation 3) fibronectin 4) P15 G1 CyclineDk TGF-B actaskinase Ligandcomes R3 +R2 + R3 R1 R3 R3present R2 interact the ligendto withR1 kinane R2/OrR2directly bind the ligend Rsmad NLS smad2/3 P smad 4 (Co srodd) is Importin Smad +cosmud NIS you with helpoflinger (in nudeu LITTLE cosmad smad PAI Transcription PAI Collagen, cell cyde Petronectin, regolation P15