MAPKinase Pathway

IAPkinase Pathway Active dimaic Mapkinase Active p90 RSK activation activation SRF SRF 2SRF oftcfby hyactive P p90 RSK TCF Mapk P P 00 TCF40 Dr SRE coding sea efosgene Transcription P13K pathway RTK PJ3 kinase 3 PIP2 P It,1,5 Tris Phosphate on membrone (act as onmembrone docting site PKB attach loet for PKB.) another name Partially activo AKT . PDK2 P PKB PDK1 & P P P a Thr P @ Ser Pollyactive various responce.

PKB Fullyactive P. P as P x B foxo3A Foxo: 1A P Es-s BAD Insdin 1 PEPCK Receptor - Tetramel Apoptosis & L2B2 G6 Phosphalase & - ligandbinding subunit. B. signal transducing sobunit (RIK) Inalsence of insolin Impresence of insolinn PKB Glycogen synthase kinase 3 GSK P GSK P GS GS active. 1 inactivated Desensilization P10phosphalase remove phosphate from PI 3, 4,5 Triphosphate Pi PI 4,5 hisphosphate. Wnl Signalling wnt - Amalgalionten - Affect winglas photopoe of diorophilla mmtv integrate neal wrt gene and increase wnt expression wingles wrt MMTV integrateneal wit

F wit act as marphagen wot modification Cias" Palmeteleicacid Biad to 7 transment receptorfisdad Canonical wot In presexed wnt batoeice Lount (Referred page wot + recepter f3 free LRPfree for figure) corrector LRP Axin complex writfier act as a scaffold for 3tinose bind and remove APC axin via Distrevelled GSK3 CK Admonates Polyposis ask3 ,ckt coredepter) COOSID kinase Choine Ap(free Bcaten/nfree molation-chobo Phophoughte enternadeus cancer LRP and act or Tf These 3 togetha P Beatenin Bcatenin) TT inactive Cellplacily Pathway wost bindo 10 f3 + a combines with Ryk for Refersion signal activate Rho at Are wrt birds to INK Actin Plymaization kinase caustropechange I TF transcriptional activation (more arelyl choline receptors, more actionmere must LBPH)