NF Signalling

NF-KB signalling (Nuclear factor Bcell) of K light chain gene Enchances on Nfk - Tf identified in enchance regioned kchain of Bcell Variou slimuli aclivate this pathway Bacterial fungi bind on Toll Like Receptor Viral infection TNf d bind to receptor IL-1 binding foreceptor ionizin radiation Inabsence of ligend Impresence of ligard P IKB NEKB free NFKB administion by Inhibitary 26sproteasomal enterhudeur IKB KB. degradation. NFKB in a heterodines Transcription activation S/G5 Inflammato Chemokines responseg ones but, TKB, are nota kinase Receptors Inflamatory cytokines to eliminate Adhesive Peot eiis Nos -> NOCCD kill the pathoger 0 Ligard binding helps the bacteria recruitment of a protein clomplex Recruitment order Descristical (I) My IRAK hy Production IKB (IF) TRAF (II) 2 Polyoniavitinate TRAF a K63. Polyobiquitinated TRAF a in docking site for TAK kinase of IKB Phosphorylate I/EB.

2Mechanisms for killing bacteria by macrophage Oxygendependent O2 independent Rosproduction defonsin, perform No etc Cantimicitial peptides) kill kill UV (non-ionizing) ionizind Radiation (xray ,rray) Pycimidine Double stronded dima Break Repair HR. NHEJ Peoteolylic Cleavage. cholestrol < HMG CoA reductive control availability enotest of LDh receptor - Tf SREB SREBactive when choletrol con greater than 5% SREB P cleavage when cholestrol is high it binds to SCAP activating protein : "SCAP+cholestrol securite Insulin induced Gene Protein INSBIG inhibit vesicle formation from ER so SREB in ER.

when chot & 5% Cholestrol detach from SCAP Exoplasmic side - & secreator INSIGdetach Cytoplasmic Precessor protein side - -rscerector SREBform veside from ERto Golgi Ingolgi d secreatase cleave lominal side, expose cytosdic deavagesite& vecoreatase cleave at the site cleaved portion is SREBP Tfof HMG coarreducture & LDL receptor unfolded protein responce cleaved reside ATF6 normally TFof heatsback birdwith good Bip, protein byxt creative ATF6. TFob HSP Amyloid Precursor Protein @ Nervecell as Exoplasmid (APP) normal cleavage & side secietas r secreatase on cyteris. cleavage Inapropriate with Brecrealase generat 12aa extracellula IHaa on membs segment & 28 aa- extracellolar damain 12transmemb segment aggregatetogether to form amyloid plaque Nave cell death Alshimer's.