Immunoglobulin

, airlier travelibes translate a singlipartion Aringle gone of the immencedatin gene we have stigtcb togelber the segments genefragraet Translated to day G.re Rearrangement Ig e definentgers sugments for L & H chain Light Cbain vsegment Vregion (L) enceded by Jsegment e region encoded by (gene segment Heavychain V VH D J Klightchain lows. (Kappa) onchoroexome 2. 3Ig gene locus Might chain locus etromoome 22 Heavychain lows etromexare 14 Kchain DNA JK CK Vk: VK2 VEn s' 101⑆0 5 2.5 23kb Kb headersequen multiple V multiple K heada peptide goide protein through single C. ER during protein trafficking

Achain 1 ONA ¥ 73 s T L VA2 Jr2 CA2 CIA VAI J)3 CA3 IT, Crs Heavy Chain DNA THIS JHACe Cg (rs (r) Cy2b (r2a CE Ca 00-00 5' L VH L VHT D111 DII" Sheeting process- - VDJ recombination 00000 L VKI L vest 1k CK Reauonged k chain DNA L VKJ IK CK 1 RNA transcript LVJCK mRNA (A)n LVICK nascent polypeptide now VK CK VJ Ch. mer K light chain VK CK