B-cell Activation

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a Bro Bcell Stage - heavy chain reauongement RAGI and RAG2 expressed in - a the Bcell stage - hight chain recouragement those 2 stages G formature Bcell - IgM, 1gaRB are proxestadion Bcellmemb stage start occuring @ Pre Bcellstage itself. a mature Bcell -lgD also expressed stage TF required for Beell Development BEES E2A EBF SOX4 BSAP Early Bcell Spocific Bcell Activatory Protein factor 1 Ag should bind to the Bcellactivation require signals Bceil receptor Costimulatory molecule 2 interaction. Igx, B cytoplasmic side has ITAMs IgGIS ITAMS. Immunoreceptor Tyrosine Based Activation Molid B7 Clars IIMHIC +++ costimulatory in molecutes 29 CDA, CD21, CD81 + B7 expressed CO22 -ve regulator deactivation of Bcells . on Bcellmentrione- 1g M/D + 1gx,B + Class (IMHC + B7 + ca19,20 81, CD22 (-ve) C C C