Tcell Maturation

Tcall materation HSC Teallprogenitor migiate to Hygnes (through cartin medulla junction) further development takesplace @ cortex T cell precursor (no receptors coreceptors) DN cells Double negative (no CD4 (no CD8) 4 subsets ekit,0044 DN2 (nocauseds) here rearrangement ekit, cd25 DN2 CD44 vay bw Brr, 68 occuring DN2 stage Bcombinet Cd25 DN3 with prea to CD3 for pre Tcell Receptor DN4 CD25,CD44 ,clat* will abobe present Developto Dooble Positive botb CD4+ CD8 express RAG-2 enzyme Rapid proliferation RAG24 when rapid @medullary epithelium prodiferation deorease AIRE modify self chain rearrangement & occurs ongs this helps in -ve selection Thymic selection 2 1 +veslection - ve selection. ocairsfirst @ medulla by medullary emithelial cello

Double positive single positive conf CDS CD//CDS Explained by smodels Instructive Electronic model model rs based on interaction Randomly berriff If the DP Tcell in intending the expression of with Clais I MSHC becomes CDS one of the receptor of Dr Teells in in leading ear or CD8 & with class II MHC bcomosCD4+ TH Tc Tcell activation agbound to MHC should interact CD4 it Costimulatory molecule interaction Ag CD28 Interaction APC BY APC APC wt T Class IIMHC TCR 00 activation BELLY Tcell NFAT (501)2 nocell indificiation Don't ITAM VSE Calceneurin T combinewith AP and act as Teaf IL2 TF of 1h2 complex P bind to immono NFAT NFAT >alaneros P ZAP JUN,MX 70(0) philin Dockingsite for ZAP70. Cyclosporin Calceneurin 3 3 P of adaptor molecules Immonosopressor) activate SLP, GADS LAT 76 4 1 P PIP2 dockingsite H cu2+cd P for PLCr, GEF. Ca2 1821P3 DA