Genome imprinting

Genomic imprinting If 2 alleles are active DNMT3add melt Dioorder grapt DNMT: 16 the methy group Inactive fof F somatic cell CH3 BB maintainine pallan JGF gene organismest Georline cell methylation 88 eased sponnato Gother 00 0 mother try to reserve glacosetor genesis. deliver las glucose to nexted joetos foelus foclus counter act &produce prolactin Reduce Insolin Gestational Diabetes Molisas increase insolin production Reduce bloodgucose compensation. foctus produce canuda actingprotection and decrease insol Inacashlood gluces G

Mt Delivered throughogs little inpotten They Developed a newgon 2ms+ Aldehyde kill hpetal cell Cytoplasmic nucleus cocunteract malesfecility RFI (Restorefactor) Aldehyde dehydrogenase Degeade Aldehyde Genome Imprinting Igd onealle onlyactive Pottasium channel Maternal Patenal Maternal Patanal. active active inactive Inactive for 0 8 for H3Ka / H3 K27 Methylation Inactivation (HPI). CH3 CH3 CH3 CH3 CH3 CH3 1 Replication CHS CH3 altamte H. (moot metholation in H3) Meliylation retainedin

custifis, CH2 enjoy HIT CH3 Dosage Compons ation only one X I socompons ated in Drosophila mail Mammals C.elegans xx, X xx,x xx,xy Random hyperactivation inactivation bypoactivation. activator protein but XO Y active Intibiles follyactive leadsto LIMITED I proteio. x x x y ternersyndione y 2 long Non coding RNA uncruk) 2 x active upto 16th day Rox 1,2 of cleavage combine with H3K16 acetylase Then inactive randomly H3 KH methyl trasjaa Morsaic pattern in calico cat. Actaractivator Coat Icell IIcell inst descendent 11 activ Inactivation cells (CH 11 combine with PRC & HDAC (CH) 11 142 (HH) numelous (egof lnc RNA) CH3 remain in nucleus @ the producing chromosome highly condensed XIST) 17kb splice 40kb 10 okb XIC Bassbody transcript seq (only active transclipt gene in have body)

active X chromotome Early X inactivation maintain TSIX Entry site for xist localization Mid x inactivation InHalbinding to potential I site (most active genesswitched PRC142 & off first Terminal inactivation H3K27 me Potential sites spread of throughout the X chromours and xis bindsto thesite Tetrado toxin Ie. Saxi toxin Sodium Channel in closed confirmation Veratridine ve Na2+ Channel in Batra cho toxin openconfirmation. Tubocoratine fromsmallscie To Cob ra toxin Nicoline Acetyl Choline as cobravenom " Bangarotteen Receptor toxin from common snakeinTaison in Atrapine Muscaline acetyl choline. (dilate Receptor thepopil)

Acelylcholin o muscaunic acetyl choline recepto (heart) slows down heart beat,heast muscle relaxation. Acctyl choline Esterase Covalently binding Non covalently binding inhibitor inhibitor DIMA PASOT Neosligining DIPF Malathion Physostiginine Pauathlon Sorip Taban. Serpestine GPCR Neurotrans milter /11 antiporta Reserpine Na2 Reuptake synaptic cleft Cocane Nat Neurotran smitta sympor