Pyruvate Dehydrogenase Cycle in Microorganisms

Reaction Mechanism of the Pyruvate Dehydrogenaic Complex. 1 Pyruvate loses W2 and 2 Hydroxyethyl gp. 3 Acetyl go is HETPP is formed IS transferred to lipoic transferred to CoA. acid and oxidized to COASH SCOA form acety dihydrolipoats 4 lipricaid is rexxidized 3 H (H3 coo- Thiamine CH3 S Pyrophosphate SH SH pyruvato NAD+ 2 4 [FAD] protein W2 CH3 NADH+H+ CH-OH - \ TPP Hydroxyethyl IPP S- HETPP) liporaud. \ pyruvate Dihydrolipay transactylace Dihydrollpayl dehydrope dehydrogenanc (Dinycholipoamicle (Dihydrolipoamide acetythansfercus) dehydrogenave)

Stage 1 and 11 - Preparatory and Redox reare Stage 1 - - A series of Preparatory rearrangements roans O that d not involve ordn - redn and do not release energy but t lead to the pdn from glucose of two D molecules of that k intermediate glyceraldehyde 3- phosphate . Stage 11- Oxdn-redn occure energy is conserved in the from of ATP, and two molecules of pyruvate are formed. Stage 111 - A second oxdn -redn rean occurs and fermentation pdts ( for lx ethand and W, or lactic acid )are formed Pdn of formentation pdt. either arrobic / Anaerobic glywhysis. -biahemical pathy for formentation of glucose / Embon on-mayorhof , Glywoyysis - Occurs in cytoplasm of both Prokasyota. H can occur either in the Presence /Absence of O2 Stage -2 Glycolysis ,Entner 1 Dardoroff Duthway, pentose phosphate Pathway