ATORVASTATIN genene - STATINS" Upitor - Brand |trade Therapeutic class : Antihyperlinidemic Pharmacologic class HMG -COA reductase inhibitor S TATN Action /uses : Hyperlipidemia to reduce MI /stroke to prevent cardiovascular disease in at risk pts t diabetes smoking/HIN / HX of family I disease. STATINS INHIBIT HMG COA REDUCTASE CHOL. LDL (Results in 2 WKS) complemented T : diet / excersice low Sat fats program cholesterol Herbal/Food AVOID GRAPEFRUIT JUICE (prevents metabolism) RED Yeast Rice - contains natural statins toxic levels can effects of atorvastatin Statins can + synthesis of coenzyme W10 (COCID) take supplements CUQ10 IS essential to produce ATP Dose: 10-80mg PO daily. R/O Heartattacks/sp capable of producing 50 / drop in LDL ml, HTN migraines, parkinsons, immune prevents blood vessel damage S/P St.
Route po Tfood (to & GI discomfort) Time: Anytime pregnancy OAT.X Q tx for overdose ONSET:2 WKS PEAK - 1-2HR DURATION UNKNOWN A/E: Hepatotoxicity Rhabdomyolysis S/E GI complaints / cramp ing/diarrheal /constipation CONTRAINDICATIONS liver discase serm transaminases prior reaction/Hypersonsitivity to dmg LABS cenim transaminase - and creatinine DRUG INTERACTIONS interacts T A 201 antifungals HIV protease inhibilors rhabdo and r/o myopathy Telaprevir levels of digoxin t oral contraceptives can Atorvastatin levels 40% Frythromycin macrolide ABX - rhabdorisk] cyclosporine/Niacin AVOID E THANOL