Procainamide

Procainamide, CLASS blocker Pharmacological class Sodium channel blocker procal Natmide Therapeutic class: class IA antidysrhythme Natchanne actionsluses. (chemically rlt anesthetic procaine.) blocker - Blocks Na lon channels in myocardial cells,thus reducing au tomaticity and slowing conduction of the action potential accross the myocardium = enlonged retractors period =able to suppress dysrhuthmias (can correct atnal/ventracular dysthythmias.) -IV or im. Therapcutic scrum drug level (4-8mggml) delays repolarization -use surine position during IV admin b/c severe hypotension may own pr regnancy CAT:C procainamide admin in Supine position onset: IV immediate peak.- 1-1-5HRS Duration 3-4HRS Im 10-30mins. ale: n/v ,abd pain Hypotension, HA/ HIGH DOSES = CNS effects confusion / psychosis BLACK BOX WARNING prolonged administration = 1 titer of antinuclear antibodies (ANN'S) Lupus- like syndrome may own in 30-50/ pts who take it 1/yr. use for life threathining dysrhythmias only b/c It can produce new

-Agrahulocytosis bone marrow depression ,neutropenia, hypoplastic anemia, dysrhythmias or worsen existing ones. and thrombocytopenia have been reported T/in 3 first months of therapy. -monitor CBC and d/c if signs of blood dy scrasial blood disorders) contraindications: plc t complete Alblock severe HF blood dyscrasias myasthema grows. interactions: drugs: tanndysrhythmics 2 additive cardiac depressant effects T anticholinergic drugs = additive anticholmergic s/e LaB tests PAST,ALT, ALP,LOH, billtubin. anticholinergic effects: False(+) coombs test and ANA titers. Inhibit the parasympathetic NS by blocking the Herbal I Food Q binding of Ach to its receptor nerve cells TX overdose: Hypotesion tx T lasopressurs tx/preventing procainamide induced dysphythmas