"PRILS"- are Angiotensin converting enzyme ISInopril -gen YOURACE Inhititors ACE Inhibitor inhibitor. (Prmvil, Zestri)-trade Dose:10mg/day Therapcutic class : prug for HF and HTN ( max 80mg/day) Pharmacological class ACE Einhibitor. Valdosteron e, V Nat reabsolpten K+ in blood cantead to hyperkatemia action/uses: HF/HTN. Inhibits ACE and decreases aldosterone secretion. BY is and cardiac output k anglotensm? IS d convened to Angina dH lack of - 2-3 wks for max effectiveness several months for hml Cardrac function - improves survival in pts when given T/In 24 hrs of an amte OIL - Fixed dose combos ( llsinopril and hydrochlorthraude) -for HIN ex: Prinzide and estorche) - fr migraines loff-label indication) . administration Alerts: Check BP prior to admin - Safel efficient for children let - doses for older ppl T CKD to prevent toxicity. Pregnancy CAT: C (first trimester) d/c If pregnancy D (2nd trimester 3rd IS suspected onset: IHR peak: 6-8HR BLACK BOX WARNING Duration: 24HR Feral injury/death If taken duning pregnancy A/e: tol hell (mostpts) common s/s cough, HA dininess, rash, orthostate hypotension. Hyperkalenny (monitor elemonytes) teste disturbances, chest pain N/V diamea
senous a/e: angioedema (Remember AKB'S and ACE'S angioedema) contraindications: in pts T hyperkalemia But only ACETS pts t previous angioedema cause cough! pts who are pregnant GARBIS interactions: use CHIN Drug: or divretics NSAIDS & will hypotensive divretics. action HINacrivity use I (Tektuma) allskiren hypotension and CKD Hyperkalemia when use T pot.sparing valsartan T sacubitril IS contraindicated b/c use T ( lisinopril 10 angioedema l LaBS: BUN bilinbin, alkaline phosphatase, aspartate aminotransferase alamine aminotransferase (ALT) Herbal I Food: Excess intake of K+ and K+ based salt substitutes should be avoided b/c ro hyperkalemia TX overdose causes hypotension. tx TNNS orvasopressor.