Hydralazine

hydralazine (strong directlyon one)! Direct artene acting vasoaniator. acts smoothmusdle Direct acting vasodilator Therapattic class:Diug for HTN and Heart failure dose PO 10-50mg qid Pharmacological class: Directacting vasodilator max: 30mg/day actions/uses One of the firstoral antiHTN drugs -alts through a direct vasodialation of arterial smooth muscle has effect on veins (acts on arteries!) - begun T low doses, which are gradully increased untill the therapeutic response is obtained - after months of therapy tol is developed and dose may need to be - Hydralazine has been largely replaced b/c ofsafety concerns parenteral formulations of hydralaive are for the tx OF hypertensive emergency - BIDil IS a fixed-dose combination of hydralazine T isosorbide dinitrate-combo used to tx HF in African Americans, Who show enhanced response to this medication - -abrupt withdrawal may cause Rebound HTN anxiety Pregnancy CAT: C onset: 20-30mins PO peak: 1-2HR po/im Duration 3-8 HRPO 10-30 min S I'm 30-45mins IV 1-4HR IV 5 -20 mins IV direct (artery)acting vasodilator. *

a/e: HA, reflex tachychardia, palpitations,flushing, nausea, diarrhea (common 515) Receive beta-Adrenergic blockers to counteract reflex * tachycardia (If BPX, & beats faster inan attempt to raise it.) - rare: mayproduce lupus-like Syndrome that may persist for bt months. Natand Fluid retention potential a/e * contraindications: in pts T angina I rheumatic mitral value I disease b/c of its effect on the pts T lupus = worsening SIS. Interactions: drug: severe Hypotension (tother -NSAIDS HTN effects labs: False-positive combs test Herbal / Food: Hawthorn cause additive hypotensive effects Tx for overdose: most likely sigh of overdosage IS hypotension TX T vasopressor I IV fluids. other vasodilators: Isosorbide acts on veins 10 saiteness