Diltiazem

diltanem -generic calcium channel blocker ia chamcle (Cardizem ,cartia XT, Dilacor XI, others)-trade - Blocker Therapeutic class: Dmg for angina /HDN/dysmythmias pharmacological class: Calcium channel blocker actions luses inhibits transport of CA into myocardial cells -relaxes coronary and penpheral blood vessels. -brings more oz to myocardium and reduces cardiac workload -PO for stable and vanant angina t HTN -IV route for tx of atrial dysrhythmias administration alerts: - monitor N admin - -various FR forms have d/ff dosages-do Q interchange - ER tabs I caps-do scrush/SPHH. Pregnancy CAT:C onset IR 30-60mins Peak: IR 2-3HR Duration IR 6-811 ER 2-3HRS ER : 6-1111R ER 12HR N 3mins CCC - -constipations cont. Infasion: 0.5-10HR constipation! can cause a/e: a senous and rt vasodilation HA, dizliness, edema of an kles/ feet Abnort Withdrawal =aute anginal episode contraindications In pts T acute mi, AV ablock, SICK sinus Syndrome, severe hypotension blending aneurysm, intracranial SX.

use T caution in pts T CKD of hepatic impairment interactions: drug-concumentux T other cardiovasoulardiness (d1goxm Ibeta adrenergic blockers maycause partial/complete heart block F) or HF Bdysrhythmas T elhanol bela blockers ,or other anti -HTW = additive hypoterson T dantrolene = cardiovascular Collapse (16 use together) - -may inhibit the metabolism of drugs thatuse CYP450 3A4 pathway laB tests: unknown may decrease the effectiveness of dilhacem Herbal/Food: st Johns wort and ginsener HTN effects= BF Garlic Hanthom, goldenseal may anti A B/P) TX overdose: Atropine or soprotereno) to reverse bradycardi Hypotension -txt vasopressor dopamine dobutamine) Calcum chl slow IV push to revise hypotension or block Thanked by CCB's