Digoxin

Digoxin -gen Cardiac glycoside (Lanoxin/lanexicans)-trade Therapeutic class: Drug for HF Pharmacological class Cardiac glycoside actions luses: A contractility or Stregth of myocardial contraction. It Inotrupic action) accomplished by inhibiting Nat,KT, ATPase as Not accumulates calcium lons are released from their storage areas incell. Release of CA Ions produces a more forceful constation of the myocardial fibers. 1 contractility = Tcardiac outment = allenate S/S of HE and improves exercise to). urine production and in bloodvol. (desirable range) relieving destressing sls of pulm. congestion and penpheral edema - affects impulse conduction of d. - suppresses SA node and slons electrical conduction through the AV hode sometimes used to tx dysthythmias) admin Alerts: Take ap Ical pulse \ full min, note rate/inytho/auality

onset 30-60 min PO a/e most senous - aysinginmius 5-30 min IV K careful use IF given T divresses or (KD. peak 4-6HRS po 1.5HRS IV N/V, tangue, anorex19 Visual I disturbances, Duration 6-8days Seeing HALOS ,Yellow green tinge blurring contraindications pts TAV block or ventricular dysrhythmia unrelated to HF - can worses - -older adults = incidence of a/e - pts t CKD= t dose b/c its excreted by this route -caution fuse Tpts TMI, cor pulmonale, hypothyroidsm interactions T - rto dysrhythmias Drugs: interacts C Many drugs! s T ACET'S /spironolactone supp - hypekalemia and action digoxin Tother inotropic drugs a cause additive effects on contractility IBetablockers - bradycardia T antacids and cholesterol lowening drugs Labsorption ofdigox11 I T Quinidine IV CA - verapami,amiodorane, r/o dystrthmias (amything alpracolam CA - distribution = 1 rt issues) and exuction ofalgoxin = T digoxin toxicity Herbal /Food K+ supp or kt salt substitute should obe taken TX overdose can be fatal tx overdose: 7 IV infusion of digoxin immune fab(Digibind) specific has antibodies for digox