Amiadarone

amiadarone (pacerone) Potassum Channel Blocker. therapeutre class. Class III antidysrhythmic umladorane -Sounds like aldactone pharmacological class: Potassium channel blocker. also works potassium actions/uses: tx of resistant ventriulartachycardia and preferred tx of atnal dysrhythmias in Pts +1 HF - (k+ always It D) potassium channel block ex blocks potassium NO channels and some Nat channels & availas oral tabs / IV (IV is short term 2 (Adays) causes PNA like syndrome pulmonary toxicity requires 10-gram * loading dose to achieve study concentration in blood doses are in first 2-3 weeks. Effects can last 4-8 weeks after d/c b/c H has -Therapeutic senin IVI 15 0.8-2.8mcg/mL Pregnancy CATD extended half life 500days) potassium Channel blocker - conect K+ and mg prior to Initiating med(blc can cause dysrhythmuas) pregnancy CAT :b onset: 2-3 DAYS PO peak 3-THKS Duration 10 50 days 2HRS IV

ale: must senous all is pulm. toxicity can cause liver enlymes Thyroid disfunction blue-gray Skin discolaration, prolonged half life=gle slow to resolve blurred vision rashis, photosensitivity n/v anorexia, tangue, dhamess, Btb. Black BOX WARNING ONLY FOR ORAL FORM causes PNA-like syndrome in lungs (may be falal) baseline /periodic assesments of lungs needed. - prodysrhythma action maycause bradycarlia ,cardiogenic Shock ,or AV black. contrandications, pts 1 severe bradycardianc avebogenic shock ,SICK sinus syndrome, mild liver injury Severe sinus node dysfunction, 310 degree Av block * tidose of warfann) Interaction beta adrenctic # can block antagonists metabolism 6Y CCBIS of warfar may in worsen (give sinus brady, reffectiveness sinus arrest T Herbal Food: I St. Johns wort laBs: or Av block. AST,AUP,ISH,J4. Grapefruit juice may toxicity of amiodanmy ANA, , ALT , TX overdose TX of amiodanne overdose is targeted on reversing hypotension T vasopressors; and bradycardia tatropine or 150 proterciol