Verapamil

verapamil (calan, covera HS, Isort In SR, ,vereian) calcium channel blocker Therapeutic class : Class N antidyschythmic Pharmacolog 10al class calcium channel blocker actionsluses inhibits flow of calcium Ions into myocardial cells and in vascular smooth muscle In 0, action slows conduction velocity and stabilizes dysrhythmias in vessels, calcium channel blockade BP, cardiac workload - dilates in tx angines. - avail. in po(ik/ek)and N. - swallow whole do scrush Ictew loven. - Ivadmin - make sure 501. IS clear/colorless. * Pregnancy CAT:C CCC onset PO 1-2HR peak: 3090 min Duration : 6-8HR can cause IV 1-5mins 4-8HK ER 12 HR ER constipation a/e generally minor and include HA flushedskin constipation, hypotension bradycardia/v contractility (monitor HF pts)

caution t use in pts I CKb/hepatic IMP airment bic can delay bleeding anenryson / pts undergoing IC sxan pts T HF contraindications: in pls I Av I block SICKSINUS Syndrome, severe hypotension elearance of med. interactions T digoxin both able slow to conduction blood through the Avnode, monitor carefully to avoid levels opdigoxin Tother bradycardia. HTW meds, may cause additive hypotension I statins = of myopathy LaB Tests: 4 Herbal/Food Grapefruit juice and substances containing affeine May Verapemil levels. Tx overdose: hypotension tx T vosupressors I doyamine 1 horepinephrire) CA salts such as CA (hl may he admin to T the amount of CA available to the myocardium and artenoles.