Ferroptosis

Ferroptosis FERROPTOSIS 00:10 Iron dependent pathway of cell death by lipid metabolism Term coined by Dixon Excessive intracellular Fe induce Reactive Oxygen Species (ROS) Exhausts Glutathione Antioxidant mech. Unchecked Lipid Peroxidation Membrane dysfunction Complete loss of Membrane Permeab. Necrosis like cell death Electron Microscopic Findings - Loss of mitochondrial cristae - Mitochondrial outer membrane rupture - mitochondrial amorphous densities MECHANISM OF FERROPTOSIS 05:00 GPx Glutathione peroxidase Oxidises GSH

Defemoxamine SLCBA2 Erastin SLC7A1 Cysteine Sulphasalazine Fe3t Fe3t Cys GSH GP GSSH Fe2t Ferroptosis OOH OH ROS (Peroxide) (Alcohol) LPCA73 PUFA PE4 PUFA Vit E . Ferrostatin Conversion of Peroxide to Akchol prevents cell injury Causes -Inhibition of GPx by RSL3 -RAS selective lethal small md.B Peroxide FIN! 56 ROS -Inhibition of SLC3A2 by drugs like . erastin Ferroptusis Sulphasalazine - Inhibition of LCAT by Vit E & Ferrostatin Ferropturi - -Entry of iron inhibited by Deferoxamine Iron supplements are not given in patient c inflammation