Lecture Note
1-Drug A has an ED 50 of 30 nM and a maximum effect of 95%. Drug B has an ED 50 of 95 nM and a maximum effect of 100%. Drug C has an ED 50 of 150 nM and a maximum effect of 40%. Which of the following is correct? A. Drug B is the highest efficacy B. Drug c is the most potent and has the lowest efficacy. C. Drug A is the most potent drug D. Drug B is the most potent drug 2- Which one of the drugs mentioned in Q1 has the maximum efficacy: A. Drug A B. Drug B C. Drug C D. Drug A and B 3- As regards the following figure, which of the following statements is correct: A. Drug A has the highest efficacy B. Drug C has the highest efficacy C. Drug B is the most potent D. Drug A is the most potent 4- As regards the previous figure, which of the following statements is correct: A. Drug C is a partial agonist B. Drug A is a partial agonist C. Drug B is an inverse agonist D. Drug C is a full agonist 5-Drug A induced a dose -induced increase in contractility of an isolated heart ( EC 50 of 30 nM of a maximum effect of 100%). In the presence of drug X, drug A induced a dose induced contractility of isolated heart (EC 50 of 90 nM of a maximum effect of 100%). In the presence of drug Y, drug A induced a dose induced contractility of isolated heart (EC 50 of 60 nM of a maximum effect of 50%.Which of the following statements is correct? A. Drug X is a non-competitive antagonist
B. Drug Y is a competitive antagonist C. Drug X is a competitive antagonist D. Drug X is a physiological antagonist 6-A competitive antagonist is : A. Irreversible B. Reduce the efficacy of an agonist C. Reduce the potency of an agonist D. increase the potency of an agonist
Exploring Drug Potency and Efficacy Variations
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