FORMATION Blood stem osteoprogenitor cells ostoclast cells precisor And brease " osteoblast Griant multinucleated -immature secretes cell matrix (osteoid) Extensions corganic (communi- cation) osteocyte bone dissolved here osteocyte reabsorption lacina - -mature mineralized (hard) Secrete proteolyti C - osteocytes cannot go back to osteoblasts enzyme secrete HCI- dissolve mineralization release Endosteum (ca2+) osteprogenitor osteoblast found in the membranes along of osteoclasts. Periosteum osteocytes (not part of membrane but within bone tissue)
COMMUNICATION bdecaptor bind so bind ranici can't rainic. OPG t RANK receptors RANKL * promote TRANKL: formation A osteoclast action of in reabsorption osteoclasts of bone (break down) Get electrical signals OPEr: physical stress RANK/RANKL binding signal to reabsorption of bone steadalst to build more bone. All bones have Extracepular Matrix calcified Osteoblasts osteoid collagen fibres Calcium E proteogly, cans phosphate until soluble Glycoproteins hydroxyapatite Run parallel (called lamallae) crystals organic (1/3) + inorganic (2/3) = Healthy bone * collagen fibres allow for flexibility and inorganic portion allows for strength Need each Other for strong bone.
Bone organ compact spongy bone cells Thickest in Diaphysis of extracellular matrix long bone Periostam external internal osteocyte central canal houses blood supply Inerves blood supply diffuse osteons Out Trabaculae Spongy Bone blood supply diffuse in compaet osteocyte bone (more solid, dense) ((exterior) filled w/ bone manow and spongy bone Periosteum blood vessels (interior) osteocytes are in bone cells osteoprogenitor osteolosts A osteouytes in membranes Cendusterm mainly
OSTEON Contractor concerning v orthangte extensions Ostcoblast Lawni a Collagen Fibers Organic Proteoglycans O-canaliculi Inorganic Hydroxyapatite Crystals supplies diffuse out osteocytes found b/w lamaliae reach out to each other A collageparallel - increase strength central canal size of for communication osteon limited but supplies. we have multiple ones. Supplies spread through layers of osteons. osteons concentric lamallae t only in compact bone opening large enough Compact for bloodvessel= Bone endosterm present. internal circumferencial lamallae Spongy & spongy squished together b/c easier for supplies to diffuse in parallel lamallae in spong bone endosterm present here